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UID:20250811T152440EDT-4508Cd9iKm@132.216.98.100
DTSTAMP:20250811T192440Z
DESCRIPTION:\n	Seeing ribosomes assemble: structural and biochemical studies
  of early eukaryotic ribosome assembly\n\nDr. Malik Chaker-Margot\n	Univers
 ity of Basel\n\nRibosomes are assembled in a remarkably complex process. E
 ukaryotic cells require some 200 non-ribosomal factors which coordinate th
 e folding\, modification and cleavage of the ribosome RNA\, the incorporat
 ion of ribosomal proteins and the quality control necessary to lead rise t
 o the small and large ribosomal subunits. Ribosome assembly begins in the 
 nucleolus where RNA polymerase I transcribes the large 35S pre-rRNA\, whic
 h is immediately bound by several ribosome assembly factors\, leading to t
 he formation of a large ribonuclear particle named the small subunit (SSU)
  processome\, which represents the earliest assembly intermediate of the s
 mall ribosomal subunit. Despite a wealth of genetic and proteomics data\, 
 little was known about the assembly mechanism and structure of the SSU pro
 cessome\, thereby limiting our understanding of the roles of early ribosom
 e assembly factors. By using cryo-electron microscopy\, we have determined
  the structure of the SSU processome to a resolution of 3.8A. Our structur
 e reveals how more than 50 ribosome assembly factors coordinate the pre-18
 S rRNA to prevent the formation of premature folding states. Combined with
  biochemical data on the assembly of the SSU processome\, these results pr
 ovide a new model on the early steps in eukaryotic ribosome assembly.\n
DTSTART:20190911T153000Z
DTEND:20190911T163000Z
LOCATION:1/12\, Strathcona Anatomy and Dentistry Building\, CA\, QC\, Montr
 eal\, H3A 0C7\, 3640 rue University
SUMMARY:Departmental Seminar: Malik Chaker-Margot
URL:/anatomy/channels/event/departmental-seminar-malik
 -chaker-margot-300398
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