BEGIN:VCALENDAR
VERSION:2.0
PRODID:-//132.216.98.100//NONSGML kigkonsult.se iCalcreator 2.20.4//
BEGIN:VEVENT
UID:20250806T215505EDT-7716onFXdi@132.216.98.100
DTSTAMP:20250807T015505Z
DESCRIPTION:www.mcgill.ca/anatomy/seminars\n\nSEMINAR POSTER\n\nTranslation
 al control plays a critical role in essential cellular processes including
  cell growth\, proliferation\, development\,and learning and memory. Under
  most circumstances\, translational control is exerted at the initiation s
 tep in which the eukaryotic translation initiation factor 4E (eIF4E) inter
 acts with the mRNA 5’cap structure to facilitate the recruitment of riboso
 mes and promote translation. Importantly\, eIF4E preferentially stimulates
  the translation of a subset of mRNAs. The activity of eIF4E is regulated 
 chiefly by two major signalling pathways: PI3K/Akt/mTOR and Ras/MAPK/Mnk. 
 mTOR directly phosphorylates the 4E-BPs (eIF4E-binding proteins)\, which a
 re inhibitors of eIF4E\, to relieve translational suppression\, while Mnk 
 phosphorylates eIF4E to stimulate translation. Aberrations in these pathwa
 ys result in dysregulated eIF4E activity\, which engenders tumorigenesis a
 nd neurological disorders such as Fragile-X syndrome and autism.\n
DTSTART:20180131T163000Z
DTEND:20180131T173000Z
LOCATION:Room 2/36\, Strathcona Anatomy and Dentistry Building\, CA\, QC\, 
 Montreal\, H3A 0C7\, 3640 rue University
SUMMARY:Seminar - Nahum Sonenberg - “Translational Control of Cancer and Fr
 agile -X via eIF4'
URL:/anatomy/channels/event/seminar-nahum-sonenberg-tr
 anslational-control-cancer-and-fragile-x-eif4-283860
END:VEVENT
END:VCALENDAR