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UID:20251221T101113EST-1636Ss9aCc@132.216.98.100
DTSTAMP:20251221T151113Z
DESCRIPTION:\n	'Human RTEL1 and genome maintenance: Telomeres or centromeres
 ? Most certainly both.'\n\n\n	Regulator of Telomere ELongation helicase 1 i
 s absolutely required for the maintenance of long telomeres and for genome
  replication in the mouse. In humans\, mutations in the gene are associate
 d with a severe form of Dyskeratosis Congenita\, the Hoyeraal-Hreidarsson 
 Syndrome (HHS). HHS patients with mutations in RTEL1 have short telomeres 
 and genome instability\, display developmental abnormalities affecting the
  central nervous system and usually die from bone marrow failure and immun
 odeficiency. We have recently shown that RTEL1 plays unanticipated roles i
 n RiboNucleoprotein trafficking\, thus potentially broadening the underlyi
 ng bases of the disease. I will present unpublished data regarding the rol
 e of human RTEL1 at telomeres as well as its role in the correct functioni
 ng of the mitotic apparatus. The implications for HHS will be discussed.\n
 \nSEMINAR POSTER\n\nwww.mcgill.ca/anatomy/seminars\n\n \n
DTSTART:20171213T163000Z
DTEND:20171213T173000Z
LOCATION:room 2/36\, Strathcona Anatomy and Dentistry Building\, CA\, QC\, 
 Montreal\, H3A 0C7\, 3640 rue University
SUMMARY:Seminar - Arturo Londono (Curie Institute) - 'Human RTEL1 and genom
 e maintenance: Telomeres or centromeres? Most certainly both'
URL:/anatomy/channels/event/seminar-arturo-londono-cur
 ie-institute-human-rtel1-and-genome-maintenance-telomeres-or-centromeres-2
 83073
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